Cat#:PA-3065F;Product Name:Mouse Anti-Human ERBB3 Antibody;Synonym:c erbB 3; c erbB3; ERBB3; ERBB3 protein; erbB3 S; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; ERBB3_HUMAN; Glial growth factor receptor; HER 3; proto-oncogene-like protein c ErbB 3; proto-oncogene-like protein c ErbB3; Proto-oncogene-like protein c-ErbB-3; receptor tyrosine protein kinase ERB3 [precursor]; Receptor tyrosine protein kinase erbB 3; Receptor tyrosine protein kinase erbB3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase type cell surface receptor HER3; Tyrosine kinase-type cell surface receptor HER3; V erb b2 avian erythroblastic leukemia viral oncogene homolog 3; v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian); v erb b2 erythroblastic leukemia viral oncogene homolog 3; lethal congenital contracture syndrome 2; EC 2.7.10; EC 2.7.10.1;Background:The human epidermal growth factor receptor (HER) family of receptor tyrosine kinases consists of four closely related members; EGFR (also known as HER1 or ErbB-1), HER2/neu (ErbB-2), HER3 (ErbB-3), and HER4 (ErbB-4). All the four members are transmembrane receptors that contain an extracellular ligand binding domain, a single hydrophobic transmembrane domain and an intracellular domain. Ligand binding to a monomeric HER member activates the cytoplasmic catalytic function by promoting receptor homo- and heterodimerization and self-phosphorylation on tyrosine residues. The latter serve as docking sites for various adaptor proteins or enzymes, which simultaneously initiate signaling cascades to produce physiological outcomes including mitosis, migration, adhesion, differentiation and apoptosis.;Description:Mouse Anti-Human ERBB3 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:DAK-H3-JD;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;