Cat#:PA-3099F;Product Name:Mouse Anti-Human ELANE Antibody;Synonym:ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase; elastase 2, neutrophil; elastase, neutrophil expressed; Neutrophil elastase; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; Medullasin; PMN elastase;Background:Neutrophil elastase (NE) is a neutral serine protease (EC 3.4.21.37) of approximately 30 kDa, consisting of three isoenzymes. NE issynthesized in the promyelocytes and promonocytes and is predominantly located in the primary (azurophilic) granules of neutrophilswhere it comprises a major component. Released from the neutrophil granules, NE acts as a potent proteolytic agent capable ofdegrading a wide range of proteins, including extracellular matrix proteins, clotting factors, immunoglobulins and complement. NE is animportant mediator in the killing of microorganisms and in the initiation of tissue injury in inflammation. NE is also considered to beimplicated in tissue destruction in pulmonary emphysema, glomerulonephritis, rheumatoid arthritis and adult respiratory distress syndrome(ARDS). Additionally it has been linked to tumour infiltration. The tissue-destructive properties of NE are counteracted by a varietyof endogenous inhibitors, including α-1-antitrypsin, human neutrophil elastase inhibitor (HEI) and elafin. The gene ELA2 encodes NE, and mutations in this gene have been implicated in severe congenital neutropenia (SCN), which may lead to acute myeloid leukaemia.;Description:Mouse Anti-Human ELANE Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:NP68;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;