Cat#:PA-3520F;Product Name:Mouse Anti-Human CD8 Antibody;Synonym:CD 8; CD 8A; CD 8B; CD8 antigen alpha polypeptide; CD8A; CD8a antigen; CD8a molecule; CD8B; CD8b antigen; CD8b antigen isoform 2; CD8b molecule; CD8B protein; CD8B1; Leu2; Leu2 T lymphocyte antigen; Ly3; LYT3; MAL; MGC119115; OKT8 T Cell antigen; p32; T cell antigen Leu2; T cell surface glycoprotein CD8 alpha chain; T cell surface glycoprotein CD8 beta chain; T lymphocyte differentiation antigen T8/Leu 2;Background:CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12. CD8 is a transmembrane glycoprotein with a molecular mass of 68 kDa. It is expressed as a disulfide-linked heterodimer comprising a 32-34 kDa α- and a 30-32 kDa β-chain, or as a homodimer comprising two α-chains. Both CD8α and CD8β have a typical immunoglubulin variable region-like domain in an N-terminal extracellular portion that makes them members of the immunoglobulin gene superfamily. CD8 is expressed mostly as the αβ heterodimer by a majority of thymocytes, and by class l major histocompatibility complex restricted, mature, suppressor/cytotoxic T cells. A proportion of γδ T cells and NK cells express the CD8 αα homodimer (3).;Description:Mouse Anti-Human CD8 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:C8/145C;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;