Cat#:PA-3518F;Product Name:Mouse Anti-Human CD86 Molecule Antibody, FITC-Conjugated;Synonym:CD86 molecule; OTTHUMP00000215511; CD28LG2; OTTHUMP00000215512; B7-2; OTTHUMP00000215513; B7.2; OTTHUMP00000215514; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); OTTHUMP00000215515; Activation B7-2 antigen; B-lymphocyte activation antigen B7-2; B70; B-lymphocyte antigen B7-2; BU63; B7-2 antigen; FUN-1; CD28 antigen ligand 2; CTLA-4 counter-receptor B7.2; T-lymphocyte activation antigen CD86; LAB72; CD86 antigen; MGC34413; CD86; CD_antigen=CD86;Background:CD86 (B70/B7-2) is together with CD80 (B7/B7-1) natural ligands for CD28 and CD152 (CTLA-4). It is a 70 kDa transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The CD86 cDNA encodes a 323 amino acid polypeptide composed of an N-terminal signal peptide, a 223 amino acid extracellular segment, a 23 amino acid transmembrane domain and a 61 amino acid cytoplasmic domain. The extracellular domain contains eight sites for N-linked glycosylation and the intracellular region has three potential sites for protein kinase C-dependent phosphorylation. The extracellular portion contains a V-set and a C2-set immunoglobulin-like domain. CD86 is expressed on resting monocytes and dendritic cells and on activated T, NK and B cells. CD86 is rapidly induced on the surface of activated B cells. This suggests that it is the major CD28 ligand and may play an important role for costimulation of T cells in the primary immune response.;Description:Mouse Anti-Human CD86 Molecule Monoclonal Antibody, FITC-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:BU74;Isotype:IgG1, kappa.;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;