Cat#:PA-3583F;Product Name:Mouse Anti-Human CD38 Molecule Antibody, RPE-Conjugated;Synonym:CD38; CD38 molecule; T10; EC 3.2.2.5; ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); OTTHUMP00000158633; OTTHUMP00000217743; NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;Background:CD38 is a 45 kDa type II integral membrane glycoprotein consisting of an N-terminal 20 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 257 amino acid extracellular domain. CD38 is associated with different molecules in different cell types and these unique combinations cause unique cell-type specific signalling. One of the known ligands that activate CD38-mediated signalling is CD31. CD38 is expressed by a number of different cell-types and the pattern of expression often changes with differentiation and maturation. Thus, CD38 expression is found during early stages of B and T-cell differentiation, is lacking during the later intermediate stages, and is regained near the end of maturation. CD38 is expressed at variable levels on the majority of haematopoietic cells, prevalently during early differentiation and activation, and it is expressed strongly on plasma cells. CD38-positive cell types outside the haematopoietic system include subsets from the gut, brain, prostate, pancreas, bone, eye and muscle. CD38 is expressed on approximately 60% of CD34-positive peripheral blood mononuclear cells. The least mature CD34-positive cells are characterized by a lack of CD38.;Description:Mouse Anti-Human CD38 Molecule Monoclonal Antibody, RPE-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:AT13/6;Isotype:IgG1, kappa;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;