Cat#:PA-3587F;Product Name:Mouse Anti-Human CD34 Molecule Antibody, FTC-Conjugated;Synonym:CD34; CD34 molecule; RP11-328D5.2; hematopoietic progenitor cell antigen CD34; CD34 antigen; OTTHUMP00000034733; OTTHUMP00000034734;Background:CD34 is a single-chain transmembrane protein of approximately 116 KDa, expressed on immature haematopoietic stem/progenitor cells, capillary endothelial cells, embryonic fibroblasts and rare glial cells in nervous tissue. CD34 appears to be expressed at its highest level on the earliest progenitors, and to decrease progressively with maturation. CD34 is a stage-specific, rather than a lineage-specific, leucocyte differentiation antigen. The most immature definable B-lymphoid precursors (CD19+/CD10+/TdT+) are CD34+. Immature T-lymphoid precursors also express TdT and CD34 (5). Normal peripheral blood lymphocytes, monocytes, granulocytes, and platelets do not express CD34. Approximately 60% of acute B-lymphoid leukaemias and 40% of acute myeloid leukaemias (AML), and 1% to 5% of acute T-lymphoid leukaemias express CD34. Chronic lymphoid leukaemias, lymphomas and multiple myelomas have been found to be uniformly CD34 negative. Monoclonal antibodies to CD34 can be confined to three main classes, class I, class II and class III, defined by the differential sensitivity of the corresponding CD34 epitopes to degradation by specific enzymes. As an example, class III monoclonal antibodies recognize a CD34 epitope resistant to neuraminidase, chymopapain and glycoprotease.;Description:Mouse Anti-Human CD34 Molecule Monoclonal Antibody, FTC-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:BIRMA-L4;Isotype:IgG1, kappa;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;