Cat#:PA-3604F;Product Name:Mouse Anti-Human CD28 Antibody, RPE-Conjugated;Synonym:CD28; CD28 molecule; Tp44; MGC138290; T-cell-specific surface glycoprotein CD28; CD28 antigen; OTTHUMP00000163782; OTTHUMP00000206300;Background:CD28 was initially termed T44 or Tp44, but was designated CD28 at the Third International Workshop and Conference on Human Leucocyte Differentiation Antigens. CD28 is a type I transmembrane protein belonging to the Ig superfamily and is a 90 kDa disulphide-linked homodimer with a subunit molecular mass of 44 kDa. CD28 is expressed on approximately 95% of CD4+ and 50% of CD8+ T cells, respectively. CD28 mediates cell adhesion through the two ligands, CD80 (B7-1) and CD86 (B7-2), expressed on activated B cells. Cross-blocking of CD28 induces T cell activation, suggesting an important role for CD28 in the interaction between B and T cells. The CD28 homologue CD152 (CTLA-4), shares the same ligands. However, this interaction inhibits T cell activation.;Description:Mouse Anti-Human CD28 Monoclonal Antibody, RPE-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:CD28.2;Isotype:IgG1, kappa;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;