Cat#:PA-3606F;Product Name:Mouse Anti-Human CD27 Molecule Antibody, RPE-Conjugated;Synonym:CD27; CD27 molecule; T14; S152; Tp55; TNFRSF7; MGC20393; CD27 antigen; CD27L receptor; OTTHUMP00000238557; T cell activation antigen CD27; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7;Background:CD27, a member of the nerve growth factor receptor (NGFR) superfamily, is a type I transmembrane protein consisting of a disulphide-linked 120 kDa homodimer. CD27 is expressed on mature thymocytes and on the majority of human peripheral blood T cells, on both CD4+ and CD8+ subsets. CD27 is also expressed on activated B cells and a fraction of resting natural killer (NK) cells. Among CD4+ T cells, CD27 is preferentially expressed on unprimed CD4+ CD45RA+ CD45R0-T cells, while primed CD4+ CD45RA - CD45R0+ T cells express low levels of CD27. During activation, the expression of CD27 is increased on B cells and unprimed T cells, while primed T cells have a relatively low capacity for upregulation of CD27. The activation is also accompanied by the appearance of a 32 kDa soluble form of CD27 (sCD27) found in supernatants of activated lymphocytes. CD27 is believed to play a role in T cell activation, since the expression is upregulated during T cell activation.;Description:Mouse Anti-Human CD27 Molecule Monoclonal Antibody, RPE-Conjugated;Host Species:Mouse;Species Reactivity:Human;Clone#:M-T282;Isotype:IgG1, kappa;Application:FCM;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;