Cat#:PA-3824F;Product Name:Mouse Anti-Human BRCA1 Antibody;Synonym:BRCA1; breast cancer 1, early onset; IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; breast and ovarian cancer sususceptibility protein; OTTHUMP00000212143; OTTHUMP00000212147; OTTHUMP00000212148; OTTHUMP00000212149; OTTHUMP00000212150; OTTHUMP00000212151; OTTHUMP00000212155;Background:This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.;Description:Mouse Anti-Human BRCA1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:GLK-3;Isotype:IgM, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;