Cat#:PA-3829F;Product Name:Mouse Anti-Human BIRC5 Antibody;Synonym:BIRC5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat containing 5; API4; EPR-1; apoptosis inhibitor 4; survivin variant 3 alpha; surviving; IAP4; Apoptosis inhibitor survivin; survivin;Background:Survivin is a member of the inhibitor of apoptosis (IAP) gene family which counteracts apoptosis by inhibiting the activity of initiator and effector caspases. Survivin associates with the microtubules in the mitotic spindle and antagonizes mitochondrial-dependent apoptosis. In addition to cell death regulation, survivin has also been shown to be important in cell division and expression is controlled at the transcriptional level in a cell cycle dependent manner. Alternative splicing of the survivin gene results in multiple transcripts including survivin-2B and survivin-Δ Ex3 which differ in their antiapoptotic activity and subcellular localization. Among normal adult tissue, survivin expression is reportedly restricted to a few cell types including thymocytes, CD34+ bone stem cells and colonic epithelium. Overexpression of survivin has been observed in a variety of tumor types and expression has been associated with poor prognosis.;Description:Mouse Anti-Human BIRC5 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:12D5;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;