Cat#:PA-3855F;Product Name:Mouse Anti-Human BCL10 Antibody;Synonym:BCL10; B-cell CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN; B-cell lymphoma/leukemia 10; hCLAP; bcl-10; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; caspase-recruiting domain-containing protein; CED-3/ICH-1 prodomain homologous E10-like regulator; mammalian CARD-containing adapter molecule E10;Background:This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.;Description:Mouse Anti-Human BCL10 Monoclonal Antibody;Host Species:Rat;Species Reactivity:Mouse;Clone#:162;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;