Cat#:PA-2716F;Product Name:Mouse Anti-Glypican 3 Antibody;Synonym:GPC3; glypican 3; SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2; glypican-3; OTTHUMP00000024058; OTTHUMP00000024059; secreted glypican-3; glypican proteoglycan 3; intestinal protein OCI-5; heparan sulphate proteoglycan;Background:Glypican-3 (GPC3) is a member of the glypican family of glycosyl phosphatidylinositol-anchored cell-surface heparin sulfate proteoglycans. The 1G12 clone has been used to assess GPC3 expression in malignant and non-malignant tissue samples of the liver. Studies have shown that GPC3 protein is expressed in most hepatocellular carcinomas (HCC), but is undetectable in normal liver and benign hepatic lesions, including dysplastic and cirrhotic nodules. GPC3 is also significantly elevated in the serum of most patients with HCC. Several studies report that Glypican-3 is a sensitive diagnostic marker for HCC and a tool for differentiating HCC from non-neoplastic and pre-neoplastic liver disease. Our TMA-based studies have shown that Glypican-3 is positive in 90.4% (66/73) of hepatocellular carcinoma cases, and negative in 100% of cholangiocellular carcinoma, normal liver and hyperplasia cases.;Description:Mouse Anti-Glypican 3 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:1G23;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;