Cat#:PA-2769F;Product Name:Mouse Anti-GATA Binding Protein 3 Antibody;Synonym:GATA3; GATA binding protein 3; HDR; HDRS; trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3; GATA-binding protein 3; MGC2346; MGC5199; MGC5445; OTTHUMP00000019070; OTTHUMP00000019071;Background:GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kDa nuclear protein regulates the development and subsequent maintenance of multiple tissues. GATA-3 orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland. GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with the expression of estrogen receptor-alpha (ER) in breast cancer, and there is mounting evidence that GATA-3 can be used as a clinical marker to determine response to hormonal therapy and to refine the prognosis of breast cancer patients. GATA-3 has also been shown to be a novel marker for bladder cancer. In one study, GATA-3 stained 67% of 308 urothelial carcinomas, but none for prostate or renal carcinomas.;Description:Mouse Anti-GATA Binding Protein 3 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:L50-834;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;