Cat#:PA-3492F;Product Name:Mouse Anti-CDX2 Antibody;Synonym:CDX2; caudal type homeobox 2; CDX3; CDX-3; homeobox protein CDX-2; OTTHUMP00000018176; caudal-type homeobox protein 2; caudal type homeobox transcription factor 2;Background:Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The protein encoded by this gene is a homeobox transcription factor. Cdx2 is the gene that directs early embryogenesis in mice. It is required to form the placenta. Ectopic expression of CDX2 was reported more than 85% of the human patients with Acute myeloid leukemia (AML). Ectopic expression of Cdx2 in murine bone marrow induced AML in mice and upregulate Hox genes in bone marrow progenitors. CDX2 is also implicated in the pathogenesis of Barrett's esophagus were it has been shown that components from gastroesofageal reflux such as bile acids are able to induce the expression of an intestinal differentiation program through up-regulation of NF-kB and CDX2;Description:Mouse Anti-CDX2 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:CDX2-99;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;