Cat#:PA-3260F;Product Name:Mouse Anti-Catenin alpha Positive Contro Antibody;Synonym:alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin (cadherin associated protein), alpha 1, 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; FLJ36832; FLJ52416; NY REN 13 antigen; OTHUMP00000224141; OTTHUMP00000224147; Renal carcinoma antigen NY REN 13alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin (cadherin associated protein), alpha 1, 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; FLJ36832; FLJ52416; NY REN 13 antigen; OTHUMP00000224141; OTTHUMP00000224147; Renal carcinoma antigen NY REN 13;Background:The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.;Description:Mouse Anti-Catenin alpha Positive Contro Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Horseradish;Clone#:BDI961;Isotype:IgG1,k;Application:ELISA, ICC, IP, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;