Cat#:PA-3391F;Product Name:Mouse Anti-Calponin Antibody;Synonym:CNN1; SMCC; Sm-Calp; calponin-1; basic calponin; calponins, basic; calponin H1, smooth muscle;Background:Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase. Calponin is mainly made up of α-helices with hydrogen bond turns. It is a binding protein and is made up of three domains. These domains in order of appearance are Calponin Homology (CH), regulatory domain (RD), and Click-23, domain that contains the calponin repeats. At the CH domain calponin binds to α-actin and filamin and binds to actin within the RD domain. Calponin does not bind to actin in the CH domain as generally described due to the fact that the CH domain is known to bind calcium to calmodulin which then inhibits actin binding. Calponin is responsible for binding many actin binding proteins, phospholipids, and regulates the actin/myosin interaction. Calponin is also thought to negatively effect the bone making process due to being expressed in high amounts in osteoblasts.;Description:Mouse Anti-Calponin Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:CAMQ;Isotype:IgG1/kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;