Cat#:PA-1577F;Product Name:Monoclonal Mouse Anti-Human Cytokeratin 20;Synonym:K20; CD20; CK20; CK-20; KRT21; MGC35423; keratin, type I cytoskeletal 20; keratin-20; protein IT; cytokeratin 20; cytokeratin-20; OTTHUMP00000164518;Background:CK 20 belongs to the intermediate filament proteins, which create a cytoskeleton in almost all cells. In contrast to other intermediate filaments, cytokeratins (CKs) are made up of a highly complex multigene family of 40 to 68 kDa polypeptides. 20 distinct CK polypeptides have been revealed in various human epithelial cells and their malignant counterparts. They can be divided into an acidic (type I) and a neutral-basic (type II) subfamily. CK 20, a 46 kDa protein, is less acidic than the other type I cytokeratins. CK 20 positivity (5-100% CK-20-positive tumour cells) has been reported in the vast majority of adenocarcinomas of the colon, mucinous ovarian tumours, transitional-cell and Merkel cell carcinomas, and frequently also in adenocarcinomas of the stomach (50%), bile system (75%), and pancreas (40%). Less than 2% of breast and lung adenocarcinomas and squamous cell carcinomas were positive, while adenocarcinomas of the ovary (non-mucinous) and endometrium, and renal cell and small cell carcinomas showed only scattered positive cells in some cases.;Description:Monoclonal Mouse Anti-Human Cytokeratin 20;Host Species:Mouse;Species Reactivity:Human;Clone#:Ks20.9;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;