Cat#:PA-1596F;Product Name:Monoclonal Mouse Anti-Human Cytokeratin 10;Synonym:BIE; EHK; K10; KPP; BCIE; CK10; keratin, type I cytoskeletal 10; CK-10; keratin-10; cytokeratin 10; OTTHUMP00000165049;Background:The cytokeratins (CKs) belong to the intermediate filaments, which create a cytoskeleton in almost all eukaryotic cells. In contrast to other intermediate filaments, CKs are made up of a highly complex multigene family of polypeptides with molecular masses ranging from 40 to 68 kDa. CKs are generally held to belong to the most fundamental markers of epithelial differentiation, and until now, 20 distinct CK polypeptides have been revealed in various human epithelia. The CKs can be divided into an acidic type A (class I) and a neutral-basic type B (class II) subfamily. CK 10 is an intermediate-sized, acidic type I cytokeratin, with a molecular mass of 56.5 kDa, expressed in all suprabasal cells simultaneously with CK 1 but is absent in basal cells. Together, CK 1 and CK 10 represent some of the first markers of epidermal differentiation. CK 10 has been implicated as marker for more differentiated cells in squamous cell carcinomas.;Description:Monoclonal Mouse Anti-Human Cytokeratin 10;Host Species:Mouse;Species Reactivity:Human;Clone#:DE-K21;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;