Cat#:PA-3140F;Product Name:Monoclonal Mouse Anti-Epstein-Barr Virus, LMP;Synonym:BNLF1; Latent membrane protein 1; EBV; Epstein Barr virus; HHV4; Human Herpesvirus 4; LMP 1; LMP1; Protein p25; Protein p63;Background:Epstein-Barr virus (EBV) is a human herpes virus, normally found as a widespread asymptomatic infection with >95% of the world’s adult population being lifelong carriers. The virus genome is a double stranded DNA molecule of approximately 172 kb encoding at least 80 proteins. Two strains of EBV exist, although the bulk of the genome appears to be identical. EBV-infected cells and neoplasms generally show one of three different expressional patterns of latency-associated viral genes. In latency type I, only EBV-encoded-nuclearantigen 1 (EBNA-1) is expressed together with two small polyadenylated nuclear RNAs (EBER 1 and 2) observed in Burkitt’s lymphoma. In latency type II, additional expression of three latent membrane proteins, LMP-1, LMP-2A and LMP-2B are observed, seen in Hodgkin’s disease and nasopharyngeal carcinoma. Latency type III is seen in lymphoproliferative diseases arising in immunocompromised individuals and EBV-transformed lymphoblastoid cell lines. In this group all six EBNAs (EBNA-1/2/3A/3B/3C/LP), all three LMPs and the two EBERs are expressed.The integral membrane protein, LMP-1, is encoded by the BNRF1 gene and contains 386 amino acids with a molecular mass of 63 kDa. It is regarded as an oncogenic protein as it is implicated in at least four transcription factor signalling pathways, and induces expression of multiple cell surface markers and cell adhesion molecules. EBV is associated with certain tumours of lympoid and epithelial origin including Burkitt’s lymphoma (BL), immunoblastic lymphoma (IBL), T-cell lymphoma, Hodgkin’s Disease (HD), nasopharyngeal carcinoma (NPC) and gastric carcinoma. The only situation where full virus replication can be reliably observed is in hairy leukoplakia, a benign lesion of the tongue frequently encountered in AIDS patients.;Description:Monoclonal Mouse Anti-Epstein-Barr Virus, LMP;Host Species:Mouse;Species Reactivity:Human;Clone#:CS.1-5;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;