Cat#:PA-813F;Product Name:Horse Anti-Human Protein C antibody;Synonym:PC; APC; PROC1; PROC; vitamin K-dependent protein C; OTTHUMP00000162263; OTTHUMP00000203820; OTT- HUMP00000203827; autoprothrombin IIA; anticoagulant protein C; blood coagulation factor XIV;Background:Protein C (PC) is a vitamin K-dependent glycoprotein produced in the liver. The concentration of PC in plasma is ~4 μg/ml (~60 nM). A deficiency of Protein C (quantitative or qualitative) is a risk factor for vascular thrombosis. Protein C is expressed as a two-chain molecule with a molecular weight of 62 kDa. The light chain (21 kDa) of PC consists of two EGF-like domains and an amino-terminal domaincontaining one hydroxyaspartic acid and 11 γ-carboxyglutamic acid (gla) residues. These residues allow PC to bind to membranes that contain acidic phospholipids in a calcium dependent manner. The heavy chain of PC (41 kDa) consists of the catalytic domain and an activation peptide. Activation of Protein C results from cleavage atresidue Arg12 in the heavy chain by a complex of thrombin and a cell surface cofactor thrombomodulin. The activation of PC is associated with the release of a small activation peptide (2-3 kDa, called Protein C peptide, or PCP) from the N-terminal of the heavy chain. Activated Protein C (APC) is a serine protease with anticoagulant activity. APC, in complex with a phospholipid membrane, calcium and the Protein S cofactor, exhibits anticoagulant activity through the proteolytic inactivation of coagulation cofactors Va and VIIIa. The primary inhibitor of APC activity in plasma is Protein C Inhibitor (PCI, also called Plasminogen Activator Inhibitor-3, PAI-3) and to a lesser extent by α1antitrypsin and α2macroglobulin. The inhibitory activity of PCI is stimulated approximately 10 fold by heparin.;Description:Horse Anti-Human Protein C antibody;Host Species:Horse;Species Reactivity:Human;Application:Blot, ELISA;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;