Cat#:PA-784F;Product Name:Goat Anti-Human PSEN1, N-Terminal Antibody;Synonym:PSEN1; AD3; FAD; PS1; PS-1; S182; presenilin 1; presenilin-1; OTTHUMP00000180587; OTTHUMP00000180588; OTTHUMP00000180589; OTTHUMP00000180591; EC 3.4.23.-; EC 3.4.23; Protein S182; PSNL1; Alzheimer disease 3;Background:Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.;Description:Goat Anti-Human PSEN1, N-Terminal Polyclonal Antibody;Host Species:Goat;Species Reactivity:Human;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;