Cat#:PA-1940F;Product Name:Goat anti-Human IgG and IgM (H&L) Antibody;Synonym:Ig gamma 1 chain C region; IGHG1; Immunoglobin heavy constant gamma 1; Immunoglobulin G;Background:Immunoglobulin G (IgG) is a monomeric immunoglobulin, built of two heavy chains γ and two light chains. Each IgG has two antigen binding sites. It is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids. IgG molecules are synthesized and secreted by plasma B cells. IgG can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by agglutination and immobilization, complement activation (classical pathway), opsonization for phagocytosis, and neutralization of their toxins.IgG antibodies are predominately involved in the secondary antibody response, (the main antibody involved in primary response is IgM). Pro-inflammatory cytokines particularly IL-4 and IL-2 have a crucial role in activation of the IgG antibody response. IgM normally constitutes about 12% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells.;Description:Goat anti-Human IgG and IgM (H&L) Polyclonal Antibody;Host Species:Goat;Species Reactivity:Human;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;