Cat#:PA-2459F;Product Name:Goat Anti-Human haptoglobin Antibody;Synonym:HP; MGC111141; hp2-alpha; Haptoglobin; binding peptide; BP; haptoglobin alpha(1S)-beta HP2ALPHA2; haptoglobin alpha(2FS)-beta; HPA1S; haptoglobin, alpha polypeptide; MGC111141; haptoglobin, beta polypeptide;Background:Haptoglobin (abbreviated as Hp) is a protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobulin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis free hemoglobin will be released into circulation and hence haptoglobin will bind the Hb. This causes a decline in Hp levels. Conversely, in extravascular hemolysis the reticuloendothelial system, especially splenic monocytes, phagocytose the erythrocytes and hemoglobin is not released into circulation and hence haptoglobin levels are normal;Description:Goat Anti-Human haptoglobin Polyclonal Antibody;Host Species:Goat;Species Reactivity:Human;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;