Cat#: | PA-3919F |
Product Name: | Rabbit Anti-Human AVEN Antibody |
Synonym: | AVEN; apoptosis, caspase activation inhibitor; PDCD12; cell death regulator aven; programmed cell death 12; Cell death regulator Aven; cell death regulator Aven; OTTHUMP00000159733; programmed cell death 12 |
Gene Introduction: | Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients. |
Description: | Rabbit Anti-Human AVEN Polyclonal Antibody |
Formulation: | Liquid Solution |
Host Species: | Rabbit |
Species Reactivity: | Human |
Application: | WB |
Usage: | For Lab Research Use Only |
Storage: | Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles |