Cat#:PA-2749F;Product Name:Monoclonal Mouse Anti-Human Glial Fibrillary Acidic Protein (GFAP);Synonym:FLJ42474; FLJ45472; glial fibrillary acidic protein;Background:GFAP is a 50 kDa intracytoplasmic filamentous protein that constitutes a portion of the cytoskeleton in astro-cytes, and it has proved to be the most specific marker for cells of astrocytic origin. In the central rod domain of the molecule, GFAP shares considerable structural homology with the other intermediate filaments. Functionally, GFAP is thought to be important in astrocyte motility and shape by providing structural stability to astrocytic processes.Following injury to the human CNS caused by trauma, genetic disorders, or chemicals, astrocytes proliferate and show extensive hypertrophy of the cell body and processes, and GFAP is markedly upregulated. In contrast, with increasing astrocyte malignancy, there is a progressive loss of GFAP production. Thus, malignant astrocytomas have fewer tumour cells that stain positively and intensely for GFAP than do less malignant astrocytomas and normal brain specimens.Outside the CNS, sensitive detection methods may demonstrate GFAP in Schwann cells, enteric glia cells, salivary gland neoplasms, and metastasizing renal carcinomas. Additionally, GFAP has been demonstrated in epiglottic cartilage, pituicytes, immature oligodendrocytes, papillary meningiomas, and myoepithelial cells of the breast.;Description:Monoclonal Mouse Anti-Human Glial Fibrillary Acidic Protein (GFAP);Formulation:Liquid Solution;Host Species:Mouse;Species Reactivity:Human;Clone#:6G3;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;