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Sheep Anti-Human Vitronectin Antibody Online Inquiry

Product Name:Sheep Anti-Human Vitronectin Antibody
Synonym: VTN; vitronectin; serum spreading factor; somatomedin B; complement S-protein; VN; S-protein; V75; epibolin; OTTHUMP00000163323; Vn
Gene Introduction: Vitronectin (Vn), previously known as serum-spreading factor or Sprotein, is a plasma and serum glycoprotein with a normal concentration ranging from 200 – 400 μg/ml. It exists in both a 75 kDa single-chain form and a 65 + 10 kDa two-chain form. Vitronectin can exist in a least two different conformational forms. The majority of Vn found in the circulation is present in the native (“closed”) form. In this form, most of the binding sites for other ligands are cryptic. The second form of Vn, the denatured (“open”, multimeric) form, is a result of a conformational change in the native protein induced by denaturants such as urea, adsorption onto surfaces, low pH or reduction and alkylation. This conformational change leads to exposure of the heparin binding site, formation of disulfidebonded multimers and rupture of the disulfide bond that links the 10 kDa light chain to the 65 kDa heavy chain of the two chain form. The liver is the primary site of Vn synthesis, however, Vn is also found in platelets, megakaryocytes, monocytes and macrophages. Vn plays an important role in a number of physiological and pathophysiological processes. It promotes the adhesion and spreading of a wide variety of cell types and is a subcomponent of the soluble SC5b-9 complex of complement where it protects bystander cells from cytolysis. Vn also plays an important role in fibrinolysis by stabilizing PAI-1 in its active conformation which otherwise rapidly converts to a latent form.
Description: Sheep Anti-Human Vitronectin Polyclonal Antibody
Formulation: Liquid Solution
Host Species: Sheep
Species Reactivity: Human
Isotype: IgG
Application: IEP, ELISA.
Usage: For Lab Research Use Only
Storage: Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles

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