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Mouse Anti-Human ZAP70 Antibody Online Inquiry

Product Name:Mouse Anti-Human ZAP70 Antibody
Synonym: ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK; STD; TZK; ZAP-70; FLJ17670; FLJ17679; zeta-chain (TCR) associated protein kinase (70 kD); Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein Syk-related tyrosine kinase; EC; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Introduction: ZAP-70 (ζ–associated protein of 70 kDa) is a tyrosine kinase of the Syk family that plays a critical role in triggering the signaling cascade in response to T-cell receptor stimulation. It is primarily expressed in T cells and natural killer (NK) cells, but is also detectable in mast cells and basophils. ZAP-70 is also expressed in normal pro/pre B cells but not in normal mature B cells. ZAP-70 is expressed in B cells in a subset of chronic lymphocytic leukemias (CLL) closely associated with an unmutated configuration of the immunoglobulin heavy-chain variable region (IgVH) genes. The precise functional significance of ZAP-70 in this subset of CLL B cells is unknown. Some data indicates that expression of ZAP-70 in CLL allows more effective IgM signaling in CLL B cells, which could explain the disease progress. Also, some other B-cell neoplasms and T-cell neoplasms express ZAP-70.
Description: Mouse Anti-Human ZAP70 Monoclonal Antibody
Formulation: Liquid Solution
Host Species: Mouse
Species Reactivity: Human
Clone#: 2F3.3
Isotype: IgG2a, kappa
Application: IHC
Usage: For Lab Research Use Only
Storage: Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles

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