Cat#:PA-008F;Product Name:Mouse Anti-Human ZAP70 Antibody;Synonym:ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK; STD; TZK; ZAP-70; FLJ17670; FLJ17679; zeta-chain (TCR) associated protein kinase (70 kD); Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein Syk-related tyrosine kinase; EC 2.7.10.2; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD;Background:ZAP-70 (ζ–associated protein of 70 kDa) is a tyrosine kinase of the Syk family that plays a critical role in triggering the signaling cascade in response to T-cell receptor stimulation. It is primarily expressed in T cells and natural killer (NK) cells, but is also detectable in mast cells and basophils. ZAP-70 is also expressed in normal pro/pre B cells but not in normal mature B cells. ZAP-70 is expressed in B cells in a subset of chronic lymphocytic leukemias (CLL) closely associated with an unmutated configuration of the immunoglobulin heavy-chain variable region (IgVH) genes. The precise functional significance of ZAP-70 in this subset of CLL B cells is unknown. Some data indicates that expression of ZAP-70 in CLL allows more effective IgM signaling in CLL B cells, which could explain the disease progress. Also, some other B-cell neoplasms and T-cell neoplasms express ZAP-70.;Description:Mouse Anti-Human ZAP70 Monoclonal Antibody;Formulation:Liquid Solution;Host Species:Mouse;Species Reactivity:Human;Clone#:2F3.3;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;