Cat#:CD3-RA01H;Product Name:Anti-Human CD3 Functional Monoclonal Antibody;Synonym:Muromonab-CD3；Orthoclone OKT3; CD3e antigen, epsilon polypeptide (TiT3 complex); DB00075 CD3E; CD3e molecule, epsilon (CD3-TCR complex); T-cell surface glycoprotein CD3 epsilon chain;Background:Muromonab-CD3 (trade name Orthoclone OKT3)was the first monoclonal antibody to be approved for clinical use in humans. OKT3 is a murine monoclonal antibody of the immunoglobulin IgG2a isotype. The target of OKT3, CD3, is a 17-20 kilodalton (kD) molecule that is part of a multimolecular complex found only on mature T cells and medullary thymocytes.;Description:Recombinant human CD3 antibody was expressed in CHO cells. Muromonab-CD3 is a mouse monoclonal antibody to CD3, often referred to as OKT3, which is used to treat acute cellular rejection after solid organ transplantation.;Source:CHO cells;Purity:Greater than 98% as determined by SDS and HPLC.;Endotoxin:< 1EU/mg;Formulation:Liquid Solution;Application:CIK cellular immunotherapy;Concentration:1mg/mL;Storage Buffer:Recombinant Human CD3 antibody was supplied in 0.2 μm filtered solution of 10mM PBS, pH 7.2.;Storage:Store recombinant human CD3 antibody at 2-8℃. Please avoid repeated freezing and thawing.;References:Bisikirska & Herold; Herold, Kevan C. (2004). "Use of Anti-CD3 Monoclonal Antibody to Induce Immune Regulation in Type 1 Diabetes". Annals of the New York Academy of Sciences. 1037: 1–9.;