Cat#:WNT3A-O197MRP;Product Name:Recombinant Mouse Wnt-3a Protein;Synonym:WNT-3a, wingless-type MMTV integration site family, member 3A, wnt3a;Background:WNT3A (Wnt Family Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include Idiopathic Juvenile Osteoporosis and Diarrhea 4, Malabsorptive, Congenital. Among its related pathways are Transcription Androgen Receptor nuclear signaling and phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex. GO annotations related to this gene include receptor binding and protein domain specific binding. An important paralog of this gene is WNT3.;Description:Recombinant Mouse Wnt-3a is a monomeric glycoprotein containing 334aa residues. Due to glycosylation, the Murine Wnt-3a migrates at an apparent molecular weight of approximately 38.0-41.0 kDa by SDS-PAGE analysis under non-reducing conditions.;Source:Cell Culture;AA Sequence:SYPIWWSLAV GPQYSSLSTQ PILCASIPGL VPKQLRFCRN YVEIMPSVAE GVKAGIQECQ HQFRGRRWNC TTVSNSLAIF GPVLDKATRE SAFVHAIASA GVAFAVTRSC AEGSAAICGC SSRLQGSPGE GWKWGGCSED IEFGGMVSRE FADARENRPD ARSAMNRHNN EAGRQAIASH MHLKCKCHGL SGSCEVKTCW WSQPDFRTIG DFLKDKYDSA SEMVVEKHRE SRGWVETLRP RYTYFKVPTE RDLVYYEASP NFCEPNPETG SFG;Molecular Characterization:40 kDa ;Purity:≥ 75% by SDS-PAGE and HPLC analyses;Bioactivity:Determined by its ability to induced alkaline phosphatase production by CCL-226 cells. The expected ED50 ​for this effect is 0.4-0.6 ng/ml.;Stability:Recombinant Proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Mouse;Species Reactivity:Chicken, Human, Mouse;Storage:Reconstituted protein is stable for at least 1 month at 4°C, but should be stored in aliquots at -80°C for longer term. Please avoid repeated freeze and thaw.;Usage:For Lab Research Use Only;References:Carthy, J M, Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-{beta} Signaling Through SMAD2 in a {beta}-Catenin-Dependent Manner.PLoS ONE; 6(5):e19809.;