Cat#:RP-0009H;Product Name:Recombinant Human TNK2 / ACK1 Protein(GST Tag);Synonym:ACK1; ACK; p21cdc42Hs; ACK-1;Background:Gene ID: 10188. TNK2, full name is tyrosine kinase non receptor 2, also known as ACK1,ACK,p21cdc42Hs, ACK-1.This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008];Description:A DNA sequence encoding the recombinant human ACK1 protein(isoform 1) was expressed in Baculovirus-Insect Cells, fusedwith the GST tag at the N-terminus.The ACK1 protein human was purified using our unique purification method.;Source:Baculovirus-Insect Cells;Predicted N Terminal:Met;AA Sequence:Gly 110-Trp 476;Molecular Characterization:The recombinant human ACK1/GST chimera protein predicts a molecular mass of 68 kDa consisting of 592aa. It migrates as an approximately 62 kDa band in SDS-PAGE under reducing conditions.;Purity:Greater than 90 % as determined by SDS-PAGE;Endotoxin:< 1.0 EU per ug of the human ACK1 protein as determined by the LAL method;Bioactivity:Please contact us for detailed information;Formulation:The recombinant human TNK2 protein was supplied in sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol, 0.5mM EDTA, 0.5mM PMSF, 0.5mM TCEP;Stability:Recombinant human TNK2 Protein is stable for up to 1 year from date of receipt at -70℃;Reconstitution:Please see related COA for specific instructions.;Application:Immunogen, SDS-PAGE;Storage:Avoid repeated freeze-thaw cycles. Store it under sterile conditions at -20℃ to -70℃. It is recommended that the human ACK1 protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.;Usage:For Research Use Only!;