Cat#:RP-5081H;Product Name:Recombinant Human PKM2 Protein;Synonym:pyruvate kinase muscle isoform M2; PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; PKM; pyruvate kinase M1/2;Background:PKM, the full name is pyruvate kinase M1/2. Gene ID: 5315. This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011];Description:Human PKM2 Protein expressed in E.coli is a single, non-glycosylated, polypeptide chain having a molecular weight of 62.4 kDa. The PKM2 human was fused with an amino-terminal hexahistidine tag. The PKM2 is purified using our standard chromatographic methods.;Source:E.coli;Purity:Greater than 95% as determined by RP-HPLC and SDS-PAGE.;Formulation:Recombinant human PKM2 protein is supplied in 1x PBS and 50% glycerol.;Stability:Recombinant PKM2 Protein is stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Storage:Store the human PKM2 protein at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.;References:LincRNA-p21 suppresses development of human prostate cancer through inhibition of PKM2. Wang X, et al. Cell Prolif, 2017 Dec. PMID 28994148;