Cat#:RP-0838H;Product Name:Recombinant Human IGF1R / CD221 Protein (His Tag);Synonym:IGF1R; IGFR; CD221; IGFIR; JTK13; insulin like growth factor 1 receptor;Background:Gene ID: 3480. IGF1R, the full name is insulin like growth factor 1 receptor. This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014];Description:A DNA sequence encoding the extracellular domain (Met 1-Asn 932) of human IGF1 Receptor (NP_000866.1) precursor was expressed with a C-terminal polyhistidine tag.;Source:Human Cells;Predicted N Terminal:Glu 31;Molecular Characterization:The calculated molecular masses for α subunit, β subunit and the single chain of the receptor are approximately 81 kDa, 23 kDa and 104 kDa, respectively. As a result of glycosylation, the recombinant single chain, α subunit and β subunit have apparent molecular masses of approximately 150 kDa, 120 kDa and 48 kDa, respectively in SDS-PAGE under reducing conditions.;Purity:Greater than 90% as determined by SDS-PAGE;Endotoxin:< 1.0 EU per ug of the human IGF1R protein as determined by the LAL method;Bioactivity:Please contact us for detailed information;Formulation:Recombinant Human CD221 Protein was lyophilized from sterile PBS Buffer, pH 7.4;Stability:Recombinant human IGF1R Proteins are stable for up to 1 year from date of receipt at -70℃;Reconstitution:Please see related COA for specific instructions.;Host Species:Human;Storage:Avoid repeated freeze-thaw cycles. In lyophilized state for 1 year (4-8℃); Upon reconstitution under sterile conditions for 2 weeks (4-8℃) or 3 months (-20℃ to -70℃).;Usage:For Research Use Only!;References:Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone. Nordstrand A, et al. Clin Exp Metastasis, 2017 Apr. PMID 28447314;