Cat#:RP-635HAT;Product Name:Recombinant Human CLCF1 Protein;Synonym:Cardiotrophin-like cytokine factor 1;Description:CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.;Source:E.coli;AA Sequence:28-225aa;Molecular Characterization:24.6 kDa;Purity:Greater than 90% by SDS-PAGE;Formulation:Liquid Solution;Stability:Recombinant Human CLCF1 Protein was stable up to 1 year from date of receipt at -70℃;Concentration:1mg/mL;Storage Buffer:Recombinant Human CLCF1 protein was supplied in 20mM sodium citrate (pH 3.5), 0.4M urea, 10% glycerol;Storage:Recombinant Human CLCF1 Protein can be stored at +4℃for 1-2 weeks. It is recommended that the recombinant protein be aliquoted for optimal storage at -20 or -70℃. Please avoid repeated freeze-thaw cycles.;Usage:For Lab Research Use Only;