Cat#:RP-1979HAT;Product Name:Recombinant 22-255aaNCR Protein;Synonym:Natural cytotoxicity triggering receptor 1 isoform a;Description:A natural cytotoxicity receptor(NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in The human recombinant NK cell activation. The natural cytotoxicity receptors(NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30,which are expressed on circulating NKcells, and NKp44,which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46( 22-255aa) was overproduced in E.coli,. This recombinant protein was purified by FPLC gel-filtration purification, after refolding of the isolated inclusion bodies in a redox buffer.;Source:E.coli;AA Sequence:22-255aa;Molecular Characterization:26.6 kDa;Purity:Greater than 95% by SDS-PAGE;Formulation:Liquid Solution;Stability:Recombinant 22-255aaNCR Protein was stable up to 1 year from date of receipt at -70℃;Concentration:1mg/mL;Storage Buffer:Recombinant 22-255aaNCR protein was supplied in PBS (pH7.4), 1mM EDTA;Storage:Recombinant 22-255aaNCR Protein can be stored at +4℃for 1-2 weeks. It is recommended that the recombinant protein be aliquoted for optimal storage at -20 or -70℃. Please avoid repeated freeze-thaw cycles.;Usage:For Lab Research Use Only;