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Recombinant Human RANKL / TNFSF11 Protein Online Inquiry

Product Name:Recombinant Human RANKL / TNFSF11 Protein
Gene Introduction: The full name of RANKL gene is receptor activator of nuclear factor-κB ligand gene. This gene, also known as TNFSF11 gene, encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. RANKL has been identified to affect the immune system and control bone regeneration and remodeling.
Description: Recombinant human RANKL protein was produced in Human cells. A DNA sequence encoding the human RANKL was expressed with the Fc Tag at the N-terminus. The RANKL human recombinant protein was purified by our unique purification techniques.
Source: Human Cells
Predicted N Terminal: Ser
AA Sequence: Gly 63-Asp 244
Molecular Characterization: The recombinant human RANKL protein has a predicted MW of 47.9 kDa containing 431aa. The apparent MW of the human RANKL protein is approximately 56 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Purity: Greater than 85% by SDS PAGE
Endotoxin: < 1.0 EU per μg of the recombinant human rankl protein determined by the LAL method
Bioactivity: The ED50 is 1.5-7.5ng/mL
Formulation: RANKL human protein was lyophilized from sterile PBS, pH 7.4.
Stability: Recombinant human RANKL Protein is stable for up to 1 year from date of receipt at -80℃
Host Species: Human
Usage: For Research Use Only!
Storage: Store recombinant human RANKL protein under sterile conditions at -20℃ to -80℃. It is recommended that the human rankl protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
References: Leibbrandt A, et al. (2008) RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143: 123-50.

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