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Recombinant Human KAT2A / GCN5 Protein, His Tag Online Inquiry

Product Name:Recombinant Human KAT2A / GCN5 Protein, His Tag
Synonym: GCN5; Histone acetyltransferase KAT2A; hGCN5; GCN5L2; PCAF-b; lysine acetyltransferase 2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; K(lysine) acetyltransferase 2A; STAF97
Gene Introduction: Gene ID: 2648. KAT2A, the full name is lysine acetyltransferase 2A. KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]. HIV-1 NL4-3 replication requires KAT2A as replication is inhibited when KAT2A is deleted through CRISPR/Cas9 genome editing. Knockdown of K(lysine) acetyltransferase 2A (KAT2A; GCN5L2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells.
Description: KAT2A human recombinant was expressed in E.coli and purified using our unique purification method.
Source: E. coli
Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Formulation: Recombinant human KAT2A Protein was lyophilized in sterile PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, 100 mM GSH, pH 8.0) and 10% glycerol.
Stability: Human GCN5 Proteins are stable for up to 1 year from date of receipt at -70℃
Reconstitution: Reconstitute the human KAT2A protein at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Host Species: Human
Storage: Store the GCN5 human at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
References: Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells. Choudhury M, et al. Alcohol, 2011 Jun. PMID 21367571

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