Cat#:IGFBP2-01RPH;Product Name:Recombinant Human IGFBP2 Protein;Synonym:IGFBP2; insulin like growth factor binding protein 2; IBP2; IGF-BP53 ;Background:The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015];Description:Recombinant Human IGFBP2 Protein was expressed in insect cells with no tag. The igfbp2 human was purified with our unique purification techniques.;Source:Insect cells;AA Sequence:37 to 325: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ;Molecular Characterization:32 kDa;Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses;Endotoxin:< 0.1 ng/µg(<1EU/µg) of IGFBP2 protein ;Bioactivity:Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.;Formulation:Lyophilised Powder;Host Species:Human;Application:SDS-PAGE; WB; Functional Studies ;Storage:Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.;References:Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients. Hur H, et al. Oncotarget, 2017 Feb 14. PMID 28036255;