Cat#:IL15RA-006RPH;Product Name:Recombinant Human IL15RA Protein;Synonym:IL15RA; interleukin 15 receptor subunit alpha; CD215;Background:Gene ID: 3601. IL15RA, the full name is interleukin 15 receptor subunit alpha. This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010];Description:Recombinant human il15ra protein, expressed in Baculovirus, was fused with a hIgG-His Tag. ;Source:Baculovirus;AA Sequence:31-205aa;Molecular Characterization:45.6kDa (417aa) 57-70KDa (SDS-PAGE under reducing conditions.);Purity:Greater than 85% by SDS-PAGE;Endotoxin:< 1.0 EU per ug of the human IL15RA protein as determined by the LAL method;Formulation:Liquid Solution;Stability:Recombinant Human IL15RA Proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Concentration:0.5mg/ml ;Storage:The human IL15RA protein can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20 to -70℃. Avoid repeated freezing and thawing cycles.;Supplied in:Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.;References:IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Marra P, et al. Cancer Res, 2014 Sep 1. PMID 24980552;