Cat#:EIA-576C;Product Name:Human Chemokine (C-C motif) Ligand 5, CCL5 ELISA Kit;Size:96T;Sample:serum, plasma and other biological fluids;Intended use:RUO;Synonym:CCL5; chemokine (C-C motif) ligand 5; SISd; beta-chemokine RANTES; EoCP; RANTES; TCP228; MGC17164; SCYA5; RANTES; TCP228; D17S136E; MGC17164; chemokine (C-C motif) ligand 5; regulated upon activation; normally T-expressed; and presumably secrete; presumably secreted; small inducible cytokine A5; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys); member 5; Small-inducible cytokine A5; Small-inducible cytokine A5; T cell-specific protein P228; Eosinophil-chemotactic cytokine; RANTES(3-68); RANTES(4-68); T-cell specific RANTES protein; T-cell-specific protein RANTES; SIS-delta;Background:It is also known as RANTES (Regulated upon Activation, Normal T-cell Expressed, and Secreted). CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.[2] It is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans. RANTES was first identified in a search for genes expressed late (3–5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13). RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells.;Species Reactivity:Human;Application:Quantitative;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Sandwich ELISA;