Cat#:EIA-599C;Product Name:Human APOH ELISA Kit;Size:96T;Sample:serum, plasma, cerebrospinal fluid, milk, and urine;Intended use:RUO;Synonym:APOH; BG; B2G1; B2GP1; apolipoprotein H (beta-2-glycoprotein I); beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein; Apo-H; APC inhibitor;Background:Beta-2 Glycoprotein 1 (β2GP1), commonly known as Apolipoprotein H (ApoH), is a highly glycosylated protein (MW = 54,200) that is expressed in the liver and then secreted into the plasma. The protein binds to several types of lipoproteins, the most notable of which is cardiolipin. Upon binding to cardiolipin, the structure of the protein complex changes to expose a stretch of amino acids that readily binds phospholipids and other anionic substances, such as heparin, and dextran sulfate.β2GP1 appears to play multiple roles in lipid metabolism, though the precise mechanisms are not clearly understood as yet. Various genotypes show different correlations (or lack of correlations) between β2GP1 levels and either plasma lipid levels or rates of lipid clearance. However, there is considerable evidence that levels of β2GP1 in plasma, or the levels of β2GP1 antibodies, are associated with certain diseases such as liver cirrhosis, antiphospholipid syndrome (APS, thrombosis), and even some form of diabetes. For example, the reduction in plasma levels of β2GP1 correlate with severity of chronic liver disease. There is also evidence that β2GP1 is involved in the regulation of the coagulation system and the generation of antiphospholipid autoantibodies. The multiple roles of β2GP1 in various physiologic pathways clearly underscore the importance of accurate and reproducible assay methods for determining the concentration of β2GP1 in various biological fluids.;Species Reactivity:Human;Application:quantitate;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Sandwich ELISA;
serum, plasma, cerebrospinal fluid, milk, and urine
Intended use:
RUO
Gene Introduction:
Beta-2 Glycoprotein 1 (β2GP1), commonly known as Apolipoprotein H (ApoH), is a highly glycosylated protein (MW = 54,200) that is expressed in the liver and then secreted into the plasma. The protein binds to several types of lipoproteins, the most notable of which is cardiolipin. Upon binding to cardiolipin, the structure of the protein complex changes to expose a stretch of amino acids that readily binds phospholipids and other anionic substances, such as heparin, and dextran sulfate.β2GP1 appears to play multiple roles in lipid metabolism, though the precise mechanisms are not clearly understood as yet. Various genotypes show different correlations (or lack of correlations) between β2GP1 levels and either plasma lipid levels or rates of lipid clearance. However, there is considerable evidence that levels of β2GP1 in plasma, or the levels of β2GP1 antibodies, are associated with certain diseases such as liver cirrhosis, antiphospholipid syndrome (APS, thrombosis), and even some form of diabetes. For example, the reduction in plasma levels of β2GP1 correlate with severity of chronic liver disease. There is also evidence that β2GP1 is involved in the regulation of the coagulation system and the generation of antiphospholipid autoantibodies. The multiple roles of β2GP1 in various physiologic pathways clearly underscore the importance of accurate and reproducible assay methods for determining the concentration of β2GP1 in various biological fluids.
Species Reactivity:
Human
Application:
quantitate
Usage:
For Lab Research Use Only
Detection Principle:
Sandwich ELISA
Storage:
Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.
USA: 1-862-686-3631
Fax: 1-323-978-5598
Email: