Cat#:EIA-437C;Product Name:Human NPPB ELISA Kit;Size:96T;Sample:BIOLOGICAL FLUIDS;Intended use:N/A;Synonym:NPPB; natriuretic peptide B; BNP; natriuretic peptides B; natriuretic peptides B; OTTHUMP00000002506; natriuretic protein; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; Gamma-brain natriuretic peptide;Background:Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are members of a family of hormones secreted from the atrium, ventricle, and vascular endothelial cells. Three receptors, type A (specific for ANP and BNP), type B (specific for CNP and ANP) and the clearance receptor, have been characterised. The mature form of BNP, secreted predominantly by the cardiac ventricle, is formed from a high molecular weight precursor, proBNP (1-108). BNP is stored in the human cardiac tissue mainly as BNP-32, with a lesser amount of the precursor peptide, proBNP (1-108). The circulating plasma forms of BNP are BNP-32, a high molecular weight BNP form that has not been well identified, the BNP fragment and the amino-terminal portion proBNP (1-76) BNP elicits a spectrum of diuretic, natriuretic and hypotensive effects similar to those induced by ANP. Recent research suggests that natriuretic peptides are important protectors against fluid overload and high blood pressure. Control of fluid and electrolyte balance as well as circulatory homeostasis also involves other regulatory mechanism, including the renin-angiotensin system, vasopressin, and the sympathetic nervous system. The discovery of natriuretic peptides has focused attention on an additional endocrine system that contributes to diuresis and vascular tone. The biology, biochemistry and the pathophysiological role of natriuretic peptides are described in recent reviews.;Species Reactivity:Human;Application:QUANTITATIVE;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Competitive ELISA;