Cat#:EIA-428C;Product Name:Human Plasminogen Activator, Tissue, PLAT ELISA Kit;Size:96T;Sample:serum, plasma and other biological fluids;Intended use:RUO;Synonym:PLAT; plasminogen activator, tissue; alteplase; t-plasminogen activator; tissue-type plasminogen activator; TPA; EC 3.4.21.68; reteplase; Alteplase; DKFZp686I03148; Reteplase; T-PA; t-PA; Tpa; plasminogen activator, tissue type; tissue plasminogen activator (t-PA);Background:This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.;Species Reactivity:Human;Application:Quantitative;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Sandwich ELISA;