Cat#:TIMD4-01HRP;Product Name:Recombinant Human TIM4 / TIMD4 Protein(His Tag);Synonym:TIM4, SMUCKLER;Background:Gene ID: 91937. Timd4, the full name is T-cell immunoglobulin and mucin domain-containing protein 4, also known as TIM4, SMUCKLER. A type I transmembrane protein called TIM4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIMD4), which belongs to the immunoglobulin superfamily and TIM family. Low expression of Timd4 is associated with lymphotoxin deficiency. The interaction of TIM1/TIM4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients.;Description:Human TIMD4 protein was produced in human cells. A DNA sequence encoding the human TIMD4 extracellular domain was expressed, fused with a His tag at the C-terminus. The TIMD4 human was purified using our unique purification techniques.;Source:Human Cells;Predicted N Terminal:Glu 25;AA Sequence:Met 1-Leu 315;Molecular Characterization:The recombinant human TIMD4 protein has a predicted molecular weight of 32.7 kDa comprising 302 aa. In SDS-PAGE under reducing conditions, the apparent molecular weight of recombinant human TIM4 protein is approximately 60-65 kDa due to glycosylation.;Purity:Greater than 90 % as determined by SDS-PAGE;Endotoxin:< 1.0 EU per μg of the human TIM4 protein as determined by the LAL method;Formulation:Recombinant human TIMD4 protein was lyophilized from sterile PBS, pH 7.4;Stability:Recombinant human TIMD4 protein is stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Storage:Avoid repeated freeze-thaw cycles. Store mouse TIMD4 protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage.;References:TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner. Zhang Q, et al. Br J Cancer, 2015 Nov 17. ;