Cat#:PA-4218F;Product Name:Mouse Anti-P-Glycoprotein Antibody;Synonym:ABC20; ABCB1; ATP binding cassette sub family B MDR/TAP member 1; ATP-binding cassette sub-family B member 1; CD243; CD243 antigen; CLCS; GP170; MDR 1; MDR1; MDR1_HUMAN; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1; P-Glycoprotein;Background:P-glycoprotein (permeability glycoprotein, abbreviated as P-gp or Pgp) is a well-characterized ABC-transporter of the MDR/TAP subfamily. P-gp is also called ABCB1, ATP-binding cassette sub-family B member 1, MDR1, and PGY1. P-glycoprotein has also recently been designated CD243 (cluster of differentiation 243). In humans, P-glycoprotein is encoded by the ABCB1 gene. Pgp is extensively distributed and expressed in the intestinal epithelium, hepatocytes, renal proximal tubular cells, adrenal gland and capillary endothelial cells comprising the blood-brain and blood-testis barrier. Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.;Description:Mouse Anti-P-Glycoprotein Monoclonal Antibody;Formulation:Liquid Solution;Host Species:Mouse;Species Reactivity:Bacteria;Clone#:UID3;Isotype:IgG2a;Application:FCM, IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;