Cat#:PA-4076F;Product Name:Mouse Anti-Human ALPP Antibody;Synonym:ALPP; alkaline phosphatase, placental (Regan isozyme); ALP; PALP; PLAP; FLJ61142; Alkaline phosphatase, placental type; PLAP-1; Alkaline phosphatase Regan isozyme; glycerophosphatase; placental alkaline phosphatase; alkaline phosphomonoesterase; EC 3.1.3.1;Background:In humans, alkaline phosphatases (APs, EC. 3.1.3.1) are encoded by a gene family composed of four loci; three tissue-specific AP (TSAP)genes (i.e. placental AP (PLAP), germ cell AP (GCAP), and intestinal AP (IAP)) are clustered at the end of the long arm of chromosome 2, bands q34-q37, while a single, tissue non-specific AP (TNAP) gene is located at the short arm of chromosome 1, bands p36.1-p34. Thethree TSAP isoenzymes are highly homologous displaying 90-98% identity in their amino acid sequence, while TNAP is only 50-60%homologous to the TSAPs (1).In normal tissues, PLAP is expressed in the syncytiotrophoblasts of the placenta from about the 8th week of gestation, and theconcentration increases continually throughout pregnancy. Additionally, PLAP is expressed in endocervix and in Fallopian tube.GCAP is expressed in primordial germ cells during their migration through the genital ridges, as well as in trace amounts during the firststeps of germ cell maturation in normal adult testis, and in the thymus. IAP is normally expressed in fetal and adult intestinal mucosa, morespecifically the microvillous border of the epithelial cells. TNAP is expressed in a multitude of tissues, including liver, bone, kidney, lungand in the placenta until about the 12th week of pregnancy.In neoplastic tissues, PLAP has been observed in cancer of the lung, ovary, uterus and proximal gastro-intestinal tissues, while it is rarelyfound in germ cell tumours. GCAP, in contrast, is present in the majority of germ cell tumours, notably in carcinoma in situ of thetestis (CIS) and in seminoma. IAP has been detected in hepatocellular carcinoma and renal cell carcinoma. Commonly, tumoursexpress more than one AP isoenzyme.;Description:Mouse Anti-Human ALPP Monoclonal Antibody;Formulation:Liquid Solution;Host Species:Mouse;Species Reactivity:Human;Clone#:8B0;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;