Cat#:RP-4183H;Product Name:Recombinant Human KAT2A / GCN5 Protein;Synonym:GCN5; Histone acetyltransferase KAT2A; hGCN5; GCN5L2; PCAF-b; lysine acetyltransferase 2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; K(lysine) acetyltransferase 2A; STAF97;Background:Gene ID: 2648. KAT2A, the full name is lysine acetyltransferase 2A. KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]. HIV-1 NL4-3 replication requires KAT2A as replication is inhibited when KAT2A is deleted through CRISPR/Cas9 genome editing. Knockdown of K(lysine) acetyltransferase 2A (KAT2A; GCN5L2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells.;Description:Recombinant human KAT2A Protein expressed in E.coli is a single, non-glycosylated polypeptide chain containing 447aa(411-837) and having a molecularweight of 51.1kDa. GCN5 protein human is fused with a 20 amino acid His-tag at N-terminus and purified using our unique purification techniques.;Source:E.coli;AA Sequence:MGSSHHHHHH SSGLVPRGSH MGGGSNSSLS LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE YHIKHNILYF LTYADEYAIG YF;Molecular Characterization:51.1kDa;Purity:Greater than 90% as determined by SDS-PAGE.;Formulation:Recombinant Human KAT2A protein solution contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 40% glycerol, 200mM NaCl and 1mM EDTA.;Concentration:0.25mg/ml;Storage:Store human KAT2A protein at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.;Usage:For Research Use Only!;