Cat#:EIA-647C;Product Name:Herpes 1 / 2 IgA ELISA kit;Size:96T;Sample:serum and plasma;Intended use:in-vitro diagnostic;Synonym:Herpes Simplex Virus 1 and 2 (HSV); HSV 1/2; HSV; Herpes Simplex Virus;Background:The Herpes simplex virus type 1 is an ubiquitous pathogen of humans that usually causes either asymptomatic infection or mild skin and mucosal diseases. Antibodies to HSV 1 occur in about 90% of adults. Normally HSV 1 is transmitted by oral secretions or open wounds prior to the age of five. Recently in adults primary infections were observed, too. After the primary infection some viruses establish a latent state in their host cells (mostly ganglial cells). The virus DNA is integrated into the genome of the host cell, where it remains until the infected person dies. After stimulation of the host cell, recurrent infection occurs, which is called an exacerbation, when clinical symtoms appear. The recurrence may be caused by different kinds of traumas, as fever or physiological changes and diseases. Immunosuppressed persons may show a severe clinical course. HSV 1 causes different clinical symptoms in about 10% of the primary infections. HSV 1 causes 85% and HSV 2 15% of oral primary infections. The major clinical manifestations associated with HSV 1 infections are gingivostomatitis, keratitis, conjunctivitis, vesicular eruptions of the skin, encephalitis, eczema and some lethal infections of newborns. In some cases HSV 1 infection leads to a meningitis with different neurological symptoms. Persons at an increased risk for serious or prolonged HSV infections are those with eczema, severe burns or a defect in their cell-mediated immunity. The drug Acyclovir is the treatment of choice for most serious HSV infections.;Species Reactivity:virus;Application:quantitative;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:I-ELISA;