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Sheep Anti-Rat Von Willebrand Factor Antibody, HRP-Conjugation Online Inquiry

Cat#:PA-061F
Product Name:Sheep Anti-Rat Von Willebrand Factor Antibody, HRP-Conjugation
Synonym: Vwf; von Willebrand factor; von Willebrand factor homolog
Gene Introduction: von Willebrand Factor (vWF, also previously referred to as Factor VIII related antigen) is a large adhesive protein produced in endothelial cells and megakaryocytes. There are two critical functions of vWF, the first being its involvement in the process of platelet adhesion and aggregation through interaction with platelet receptor glycoprotein Ib, the second being the binding and stabilization of Factor VIII (antihemophilic factor) for secretion and transport in plasma. The vWF precursor protein is synthesized with a 95,000 dalton propeptide (also known as vWF antigen-II), believed to be involved in the intracellular multimerization of the vWF subunits. The mature vWF multimers are then packed into storage organelles within the cell (Weibel-Palade bodies) after which the propeptide is cleaved and released. vWF circulates as multimers of disulphide linked 220,000 dalton subunits and the molecular weight of these multimers ranges from 0.5-20 million daltons.The concentration of vWF in human plasma is typically 10 μg/ml, but increased levels are often observed in pregnancy and other conditions of physiological stress. von Willebrand’s disease (vWD) is perhaps the most common inherited bleeding disorder in humans and is the result of either quantitative deficiencies of vWF (vWD Types I & III), or one of a number of qualitative disorders of vWF structure and function (vWD Type II).
Description: Sheep Anti-Rat Von Willebrand Factor Polyclonal Antibody, HRP-Conjugation
Formulation: Liquid Solution
Host Species: Sheep
Species Reactivity: Rat
Isotype: IgG
Application: IEP, ELISA.
Usage: For Lab Research Use Only
Storage: Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles

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