Cat#:PA-052F;Product Name:Rabbit Anti-Von Willebrand Factor (VWF) Antibody;Synonym:VWF; von Willebrand factor; von Willebrand antigen 2; von Willebrand antigen II; F8VWF; F8; VWD; vWF; coagulation factor VIII VWF;Background:Von Willebrand Factor (vWF) is a large glycoprotein with a multimeric structure and a molecular mass ranging from 500 kDa up to more than 10 000 kDa, the latter being the largest known for a soluble human plasma protein. The primary product of the von Willebrand Factor gene, located at chromosome 12p13.2, is a 2813 amino acid protein comprising a signal peptide of 22 amino acids, a large propeptide of 741 amino acids, and a mature vWF molecule containing 2050 amino acids. Expression of the von Willebrand Factor gene is tissue specific and confined to endothelial cells and megakaryocytes. VWF is present in plasma, in the Weibel Pallade bodies of endothelial cells, in the alpha-granule in megakaryocytes and platelets derived from them, as well as in the subendothelial matrix of the vessel wall. Von Willebrand Factor serves as a carrier for Factor VIII in plasma, protecting the circulating coagulation coenzyme from proteolytic degradation. The von Willebrand disease is the most common bleeding disorder affecting 1% of the population and is caused by the qualitative or quantitative deficiency of vWF. It is classified into three main types: Type 1 is a partial quantitative deficiency; Type 2, is a qualitative defect which is further subdivided into four categories; and Type 3 is a complete absence of vWF.;Description:Rabbit Anti-Von Willebrand Factor (VWF) Polyclonal Antibody;Formulation:Liquid Solution;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;