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Recombinant Mouse RANKL / OPGL / TNFSF11 / CD254 Protein(Fc Tag) Online Inquiry

Cat#:RP-RANKL-01M
Product Name:Recombinant Mouse RANKL / OPGL / TNFSF11 / CD254 Protein(Fc Tag)
Synonym: RANKL, OPGL,TNFSF11,CD254,hRANKL2
Gene Introduction: The full name of RANKL gene is receptor activator of nuclear factor-κB ligand gene. This gene, also known as TNFSF11 gene, encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. RANKL has been identified to affect the immune system and control bone regeneration and remodeling.
Description: A DNA sequence encoding the extracellular domain of mouse RANKL/TNFSF11 (BAA97257.1) (Arg 72-Asp 316) fused with the Fc Tag at the N-terminus was produced in Human cells. The RANKL mouse recombinant protein was purified by our unique purification techniques.
Source: Human Cells
Predicted N Terminal: Glu
Molecular Characterization: The recombinant mouse RANKL/TNFSF11/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a calculated molecular mass of 56 kDa. The apparent molecular mass of the monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
Purity: Greater than 87 % as determined by SDS-PAGE
Endotoxin: < 1.0 EU per μg of the mouse rankl protein as determined by the LAL method
Bioactivity: Immobilized mouse Fc-rankl at 10 μg/ml (100 μl/well) can bind biotinylated human TNFRSF11B-His, The EC50 of biotinylated human TNFRSF11B-His is 0.07-0.17 μg/ml.
Formulation: Recombinant mouse RANKL protein was lyophilized from sterile PBS, pH 7.4
Stability: Recombinant mouse RANKL Proteins are stable for up to 1 year from date of receipt at -70℃
Host Species: Mouse
Storage: Store recombinant mouse RANKL protein under sterile conditions at -20℃ to -80℃. It is recommended that the mouse rankl protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
References: 1. Nakashima T, et al. (2003) RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3): 280-7. 2.Leibbrandt A, et al. (2008) RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143: 123-50.
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